منابع مشابه
Ancestral Components of Admixed Genomes in a Mexican Cohort
For most of the world, human genome structure at a population level is shaped by interplay between ancient geographic isolation and more recent demographic shifts, factors that are captured by the concepts of biogeographic ancestry and admixture, respectively. The ancestry of non-admixed individuals can often be traced to a specific population in a precise region, but current approaches for stu...
متن کاملEstimating kinship in admixed populations.
Genome-wide association studies (GWASs) are commonly used for the mapping of genetic loci that influence complex traits. A problem that is often encountered in both population-based and family-based GWASs is that of identifying cryptic relatedness and population stratification because it is well known that failure to appropriately account for both pedigree and population structure can lead to s...
متن کاملEstimating local ancestry in admixed populations.
Large-scale genotyping of SNPs has shown a great promise in identifying markers that could be linked to diseases. One of the major obstacles involved in performing these studies is that the underlying population substructure could produce spurious associations. Population substructure can be caused by the presence of two distinct subpopulations or a single pool of admixed individuals. In this w...
متن کاملThe genetic structure of admixed populations.
A method for simultaneously estimating the admixture proportions of a hybrid population and Wright's fixation index, FST, for that hybrid is presented. It is shown that the variance of admixture estimates can be partitioned into two components: (1) due to sample size, and (2) due to evolutionary variance (i.e., genetic drift). A chi-square test used to detect heterogeneity of admixture estimate...
متن کاملAncestry specific association mapping in admixed populations
Genetic association studies have during the last decade proven to be a powerful approach to identifying disease-causing variants. However, many populations, like the Greenlandic Inuit population, have recently experienced substantial admixture with other populations, which can complicate association studies. One important complication is that most current methods for performing association test...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2012
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.2461